This is at the heart of GlobalCures’ mission.  Without such trials, one may never know if the drugs/therapies in question are really working or not.  They may work for a while and then fail later.  They may work best in conjunction with standard chemotherapy.  They may have unexpected side-effects.  They may work only in a sub-group of cancer patients.  These are the types of questions that will be answered by the clinical trials that GlobalCures will conduct.  Most importantly, physicians will be reluctant to prescribe these therapies without such data, i.e. potential patient benefit versus risk of the therapy.  In addition, physicians worry about losing their license or being sued for prescribing unvalidated therapies; they may get derided by their colleagues, and they may not understand the rationale for the therapy or its interaction with more conventional therapies in the absence of rigorous data.